Actively Recruiting
Role of the Gut Microbiome in the Outcome of Diffuse Large B-Cell Lymphoma Patients Treated With CAR-T Cell Therapy
Led by University of Bologna · Updated on 2023-06-18
90
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
U
University of Bologna
Lead Sponsor
A
Associazione Italiana per la Ricerca sul Cancro
Collaborating Sponsor
AI-Summary
What this Trial Is About
Despite impressive outcomes in selected patients, significant heterogeneity in clinical response to CAR-T cell therapy remains. The gut microbiome (GM) has recently emerged as one of the key modifiable factors of prognosis and response to treatment in cancer patients, with high-diversity profiles rich in health-associated taxa while poor in pathobionts generally associated with better response and longer survival. Currently, it is unknown if GM also modulates anti-tumor responses to CAR-T cells and related toxicities in lymphomas.
CONDITIONS
Official Title
Role of the Gut Microbiome in the Outcome of Diffuse Large B-Cell Lymphoma Patients Treated With CAR-T Cell Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically confirmed diffuse large B-cell lymphoma (DLBCL)
- Eligible for CAR-T cell therapy as per approved clinical guidelines
- Able and willing to provide written informed consent
You will not qualify if you...
- Presence of significant, uncontrolled health conditions that could affect study participation or result interpretation
- Having another active cancer at the same time
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute Of Hematology "Seràgnoli"
Bologna, Italy, 40138
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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