Endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injection: a comprehensive review.
Rohan Merani, Alex P Hunyor
https://pubmed.ncbi.nlm.nih.gov/27847602Actively Recruiting
Led by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Updated on 2025-01-13
56
Participants Needed
1
Research Sites
52 weeks
Total Duration
This research investigates the use of Hexamidine Diisethionate (Zamidine®) eye drops to reduce bacterial presence on the eye surface before ophthalmic surgeries. The study focuses on patients with any type of recurrent conjunctivitis who are scheduled for procedures such as intravitreal injections, glaucoma surgery, cataract surgery, vitrectomy, combined cataract and vitrectomy, or corneal transplantation. The goal is to evaluate bacterial changes related to surgical prophylaxis and to monitor for post-surgery infections like endophthalmitis. Participants will have conjunctival swabs taken at multiple times: four days before surgery to detect unusual bacteria, on the surgery day before entering the recovery room, and after three minutes of applying 5% iodopovidone to the operative eye. These samples will be analyzed to measure and compare bacterial load around the time of surgery. The study collects data from medical records in a pseudonymized manner and follows standard clinical practices for the patients' conditions. During the study, follow-up information will be gathered from medical records 24 and 30 days after surgery. Researchers will assess bacterial species and quantities before and after prophylaxis, as well as monitor surgical outcomes and any adverse events. This comprehensive data collection helps understand the role of Zamidine® in surgical antisepsis and infection prevention over a period extending slightly beyond a month after surgery.
CONDITIONS
THE ROLE OF HEXAMIDINE DIISETHIONATE (ZAMIDINE®) 1MG/ML 0.6ML EYE DROPS IN THE PROPHYLAXIS OF SURGERY OFTALMIC
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Total: 1 location
1
Prof. Stanislao Rizzo
Rome, Italy, 00168
Actively Recruiting
S
Stanislao Rizzo, MD, Prof
V
Valentina Cestrone, Dr
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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