Actively Recruiting
The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis
Led by Institut Pasteur · Updated on 2025-01-23
90
Participants Needed
4
Research Sites
N/A
Total Duration
On this page
Sponsors
I
Institut Pasteur
Lead Sponsor
J
Janssen Biotech, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the role of IL-23 in the development and progression of axial and peripheral spondyloarthritis (SpA), including psoriatic arthritis, to better understand how the body responds to anti-IL-23 biologic treatments. This multicenter, non-randomized prospective study focuses on patients attending rheumatology departments in several hospitals and aims to explore the cellular and molecular targets of IL-23 signaling in these chronic inflammatory diseases. Participants are divided into two groups: those with axial SpA and those with peripheral SpA or psoriatic arthritis. The study involves collecting blood samples and, when required as part of standard care, synovial fluid from joint aspirations in peripheral SpA patients. These samples will be used to analyze gene expression, immune cell characteristics, and cytokine production related to IL-23 and IL-17 pathways over a period of up to four years. Throughout the study, participants will undergo assessments including profiling of chromatin regions, transcriptome and genome analysis, cytokine expression monitoring, and single cell transcriptome analysis. The research will also measure lymphocyte levels to observe immune responses to anti-IL-23 treatments. Participants' involvement includes laboratory tests and sample collections aligned with routine care, with the study concluding by September 2027.
CONDITIONS
Brief Title
The Role of IL-23 in Chronic Inflammatory Disease: Exploring the Cellular and Molecular Targets of IL-23 Signaling in Peripheral and Axial Spondyloarthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years old
- Diagnosed with spondyloarthritis according to ASAS criteria
- Have active disease with synovitis, tendinitis, dactylitis, or significant inflammatory spinal pain
- Have signed informed consent
- Covered by health insurance except AME beneficiaries
- For Group 1: Patient is new to biological therapies
- For Group 2: Patient has peripheral SpA or psoriatic arthritis with joint inflammation
- For Group 2: Patient requires synovial fluid aspiration as part of standard care
You will not qualify if you...
- Under 18 years old
- Pregnant or breastfeeding
- Immunocompromised
- Received two or more biological therapies
- Taking corticosteroids over 10 mg per day
- Under legal protection such as guardianship or curatorship
- Refuses consent
- History of alcoholism, drug addiction, psychological problems, or severe conditions affecting consent or compliance
- Beneficiary of AME
- For Group 1: Has received biological therapy before
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 years
Participants provide blood samples and, if applicable, synovial fluid samples collected during routine care for study analysis.
Visits coincide with routine clinical procedures; synovial fluid collection occurs only if required by standard care
Trial Site Locations
Total: 4 locations
1
Hôpital Henri-Mondor, AP-HP - Service de Rhumatologie
Créteil, France, 94000
Not Yet Recruiting
2
Hôpital Cochin, AP-HP - Department of Dermatology B
Paris, France
Actively Recruiting
3
Hôpital Saint-Antoine, AP-HP - Service de Rhumatologie
Paris, France
Actively Recruiting
4
Hôpital Maison Blanche - Service de Rhumatologie
Reims, France, 51092
Not Yet Recruiting
Research Team
L
Lars ROGGE, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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