Actively Recruiting
The Role of IL5 in Epithelial Cell Integrity
Led by Johns Hopkins University · Updated on 2026-01-12
8
Participants Needed
2
Research Sites
142 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
G
GlaxoSmithKline
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this laboratory study is the examine the effect of mepolizumab drug on the health and function of the cells lining the human nasal airways in vitro cell culture derived from patients with chronic rhinosinusitis with nasal polyposis. The main questions the study aims to study are: 1. To see what mepolizumab does to suppress inflammation of the human cells. 2. To see what mepolizumab does to maintain barrier integrity of epithelial cells
CONDITIONS
Official Title
The Role of IL5 in Epithelial Cell Integrity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sinonasal inflammation lasting more than 12 weeks with at least two of these symptoms: nasal obstruction or congestion, nasal discharge, facial pressure or pain, or reduced sense of smell
- Confirmation of sinus inflammation by CT scan showing mucosal inflammation or endoscopic exam showing purulence from sinuses or ostiomeatal complex
- Presence of nasal polyps confirmed by endoscopic exam or sinus CT scan
You will not qualify if you...
- Children under 18 years old
- Pregnant or lactating females
- Prisoners
- Mentally disabled individuals
- Persons unable to give informed consent
- Disease caused by clear anatomic problems like facial trauma or sinonasal tumors
- Use of oral or intravenous glucocorticoids within 2 weeks before surgery
- Use of immunomodulatory biologic treatments including omalizumab, dupilumab, mepolizumab, benralizumab, reslizumab, or rituximab
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21117
Actively Recruiting
2
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
J
Jean Kim, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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