Actively Recruiting
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-12-27
200
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1. Fluorodeoxyglucose positron emission tomography (FDG-PET) 2. Perfusion (and structural) magnetic resonance (MR) images 3. Computed tomography (CT) perfusion. Brain hypermetabolism/hyperperfusion is a strong argument to confirm a diagnosis of non-convulsive status epilepticus. The aim is to determine which of the three functional imaging techniques is the most sensitive and easy to obtain in the detection of hypermetabolism/hyperperfusion. The investigators will determine which EEG patterns are associated with hypermetabolism/perfusion. The investigators will further study and describe the management with antiseizure medication and outcome of the group with possible non-convulsive status epilepticus WITH hypermetabolism/hyperperfusion versus the group with possible non-convulsive status epilpticus WITHOUT hypermetabolism/hyperperfusion. The investigators will make recommendations for an imaging protocol in possible NCSE for widespread use. The aim is to offer guidelines to incorporate imaging in the diagnosis, management and prognosis of NCSE in patients with the ictal-interictal continuum.
CONDITIONS
Official Title
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The patient has possible non-convulsive status epilepticus with scalp or invasive EEG showing ictal-interictal continuum patterns
You will not qualify if you...
- The patient has a contraindication for MRI such as metal implants
- The patient has contrast sensitivity
- The patient suffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospitals Leuven, department of Neurology
Leuven, Belgium, 3000
Actively Recruiting
Research Team
W
Wim Van Paesschen, MD PhD
CONTACT
J
Jeroen Gijs, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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