Actively Recruiting
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
Led by Mayo Clinic · Updated on 2025-12-15
60
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression of PC-1/3 and GLP-1 that is observed in diabetic islets. However, its regulation is at present unknown. At present it is unknown if these abnormalities develop in prediabetes and whether they contribute to the phenotypes observed. In this experiment we will use blockade of GLP1R to probe the contribution of endogenous GLP-1 secretion to the regulation of fasting glucose and islet function in prediabetes.
CONDITIONS
Official Title
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- People with stable weight and no history of diabetes
- Fasting glucose < 126 mg/dL
- 2-hour glucose after 75g oral glucose tolerance test < 200 mg/dL
You will not qualify if you...
- Age less than 25 or greater than 70 years
- HbA1c greater than 6.5%
- Use of any glucose-lowering agents including metformin or sulfonylureas
- Positive pregnancy test at enrollment for female subjects
- History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty, or vagotomy
- Active systemic illness or malignancy
- Symptomatic macrovascular or microvascular disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
A
Adrian Vella, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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