Actively Recruiting
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
Led by Rutgers, The State University of New Jersey · Updated on 2025-12-17
120
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
Sponsors
R
Rutgers, The State University of New Jersey
Lead Sponsor
N
National Institute of Environmental Health Sciences (NIEHS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.
CONDITIONS
Official Title
The Role of Macrophage Activation in Lung Injury Following Ozone Exposure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 40 years
- Healthy individuals able to produce a sputum sample
- Willingness to participate in two exposure sessions at least 2 weeks apart
- Ability to perform intermittent exercise on a bicycle during exposure
- Ability to attend 5 study visits at the Rutgers EOHSI clinical center
You will not qualify if you...
- Cardiovascular disease
- Respiratory disease
- Recent respiratory or COVID-19 symptoms within 4 weeks
- Diabetes
- Pregnancy
- HIV infection
- History of smoking within the past 5 years
- Orthopedic or rheumatologic conditions interfering with bicycle use
- Inability to produce a sputum plug at screening
- Daily use of antioxidant supplements such as Vitamin C, Vitamin E, selenium, beta-carotene, lycopene, lutein, zeaxanthin, or ginkgo biloba (except multivitamins)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Rutgers - EOHSI
Piscataway, New Jersey, United States, 08854
Actively Recruiting
Research Team
K
Kathleen Black, PhD
CONTACT
A
Adriana De Resende
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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