Actively Recruiting
Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Led by University of Colorado, Denver · Updated on 2026-03-23
150
Participants Needed
2
Research Sites
243 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
U
University of Virginia
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal to determine whether exercise training attenuates insulin resistance and restores insulin-mediated perfusion to the heart and to skeletal muscle, leading to improved cardiac function and exercise performance.
CONDITIONS
Official Title
Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sedentary (defined as less than 1 hour per week of physical activity)
- Body mass index (BMI) between 25 and 40
- Men and women with or without type 2 diabetes
- Age between 30 and 55 years
You will not qualify if you...
- Documented cardiovascular disease
- Uncontrolled hypertension with systolic blood pressure (SBP) > 150 or diastolic blood pressure (DBP) > 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Physical impairment limiting ability to exercise
- Taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
- Current or past smoking within the last 1 year
- Current tobacco use
- Anemia
- Control HbA1c > 5.7 or type 2 diabetes HbA1c > 9
- Pregnant, nursing, or using hormonal therapy other than contraceptives
- Peri or post-menopausal women
- Type 1 diabetes
- Hepatic or renal disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
2
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
B
Benjamin Juckett, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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