Actively Recruiting
The Role of the Nasal Allergen Provocation Test in Starting and Monitoring Allergen Immunotherapy
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2026-05-01
200
Participants Needed
2
Research Sites
332 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
A
AZ Sint-Jan AV
Collaborating Sponsor
AI-Summary
What this Trial Is About
This prospective multicentric academic NAPT study aims to compile a database of all patients who initiate immunotherapy. The NAPT will take place before, during and after AIT to evaluate the cost and effectiveness of the treatment. The study consists of 4 visits and 2 telephone contacts that are repeated annually for 3 years. This study will be conducted in 2 hospitals: UZ Leuven and AZ ST. Jan Brugge on the consultation Ear, Nose and Throat Diseases (ENT) and the department of Internal Medicine / Allergology
CONDITIONS
Official Title
The Role of the Nasal Allergen Provocation Test in Starting and Monitoring Allergen Immunotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years
- Persistent or intermittent allergic rhinitis confirmed by skin prick test or immunocap for specific IgEs, or suspected local allergic rhinitis
- Starting allergen immunotherapy treatment
- Motivated and willing to attend all visits
- Able to understand and sign informed consent
You will not qualify if you...
- Uncontrolled asthma
- Immune system conditions such as immune deficiencies, malignancies, or autoimmune diseases
- Use of beta-blockers, immunosuppressants, or ACE inhibitors
- Hypersensitivity to aluminum hydroxide or any excipients in allergen immunotherapy
- History of anaphylaxis after allergen challenge
- Acute rhinosinusitis in the last 12 weeks
- Recent surgery on the nose or paranasal sinuses in the last 12 weeks
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
UZ Leuven
Leuven, Vlaam Brabant, Belgium, 3000
Actively Recruiting
2
AZ Sint-Jan
Bruges, Belgium, 8000
Not Yet Recruiting
Research Team
M
Margot Vandekerckhove
CONTACT
L
Laura Van Gerven, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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