Study of Nutrient Transit and Hormone Effects in Hyperinsulinemic Hypoglycemia After Gastric Bypass Surgery

What this Trial Is About

Researchers are investigating severe hypoglycemia, a condition of dangerously low blood sugar that can occur after gastric bypass surgery. This condition causes symptoms after eating and is linked to unusually high insulin levels during low blood sugar episodes. The study aims to understand why some patients develop this problem and others do not, to help improve prediction, prevention, and treatment options. No current medical treatments exist for this disorder, making this research important for affected patients. Participants will wear a continuous glucose monitor CGM first in a blinded mode for 20 days, then unblinded for another 20 days to track blood sugar levels closely. They will attend 1 to 3 study visits over about 2 months where metabolic tests will be done under various conditions. Some participants will undergo specialized meal tests through oral, gastrostomy tube, or combined feeding routes. The study includes different participant groups such as post-bariatric hypoglycemia patients and controls without surgery. During the study, researchers will assess glucose levels, insulin sensitivity, gastric emptying, hormone secretion, and the frequency and duration of hypoglycemia episodes. Monitoring includes wearing devices like the CGM and Cardea Solo patch. Safety and heart rhythm changes during low blood sugar will also be tracked. The total study involvement spans roughly 2 months with multiple visits and continuous monitoring, aiming to deepen understanding of this conditions physiological changes.

Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia