Actively Recruiting
Role of Pavlovian Mechanisms for Control Over Substance Use
Led by Technische Universität Dresden · Updated on 2024-11-22
200
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
Sponsors
T
Technische Universität Dresden
Lead Sponsor
C
Charite University, Berlin, Germany
Collaborating Sponsor
AI-Summary
What this Trial Is About
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs between alcohol use disorder (AUD) and control subjects. Preliminary analyses of the full transfer task indicate that AUD participants exhibit a stronger specific PIT effect compared to controls. Based on these findings, the investigators want to compare specific and general PIT effects in patients with moderate to severe substance use disorders (alcohol, cannabis, methamphetamine, amphetamine and cocaine) to healthy controls on the behavioral and neural level (fMRI).
CONDITIONS
Official Title
Role of Pavlovian Mechanisms for Control Over Substance Use
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women between 18-65 years of age
- Meet 4 or more DSM-5 criteria for alcohol-related and/or substance-related disorder (cannabis, amphetamine, methamphetamine, or cocaine)
- Currently using alcohol without a desire for abstinence
- Ability to consent and complete questionnaires
- Sufficient German language and motor skills for using a computer
- Existing health insurance
You will not qualify if you...
- Lifetime diagnosis of bipolar disorder, schizophrenia, or schizophrenia spectrum disorder (drug-induced if more than one month ago)
- Current major depressive disorder or suicidal intention
- High risk ASSIST scores for substances other than alcohol, amphetamine, methamphetamine, cannabis, cocaine, tobacco
- History of traumatic brain injury or severe neurological diseases (dementia, Parkinson's, multiple sclerosis, epilepsy, meningitis, stroke)
- Pregnancy or breastfeeding
- Use of dopamine-interacting medications within 10 days prior or less than 4 half-lives before participation
- MRI contraindications (e.g., pacemakers, metal implants, surgical staples)
- Color vision deficiency
- Sensorineural hearing loss of 30 dB or greater
- Tinnitus
- Acute intoxication with alcohol or substances (cannabis, methamphetamine, amphetamine, cocaine) on assessment day verified by breath alcohol and urine tests
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Psychiatry and Psychotherapy, Technische Universität Dresden
Dresden, Germany
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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