Actively Recruiting
Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion
Led by IRCCS Burlo Garofolo · Updated on 2024-06-13
130
Participants Needed
9
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Adnexal torsion is the fifth most common gynecologic emergency. Thirty percent of all cases of adnexal torsion occur in females younger than 20 years. Approximately 5 of 100,000 females aged 1-20 years are affected, with girls older than 10 years at increased risk because of hormonal influences and gonadal growth that result in an increased frequency of physiologic and pathologic masses. The most common clinical symptom of torsion is sudden-onset abdominal pain that is intermittent, non-radiating, and associated with nausea and vomiting in 62% and 67% of cases respectively. Moreover, abdominal tenderness is a clinical sign which is reported in up to 88% of patients with adnexal torsion. None of the following tests are useful in the diagnosis of adnexal torsion: leukocytosis, pyuria, C-reactive protein, and erythrocyte sedimentation rate. Actually, transabdominal ultrasonography is the imaging modality of choice with a sensitivity of 92% and specificity of 96% in detecting adnexal torsion. A second-line imaging tool in the diagnosis of adnexal torsion is magnetic resonance, which may require a sedation in selected cases. Consequently, there are no clinical or imaging criteria sufficient to confirm the preoperative diagnosis of adnexal torsion to date. Therefore, patients with a clinical suspicion for adnexal torsion should undergo emergent diagnostic laparoscopy.
CONDITIONS
Official Title
Role of Preoperative D-dimer Levels in the Diagnosis of Adnexal Torsion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients
- Age less than 18 years
- Presenting with lower quadrants abdominal pain
- Imaging suspicious for adnexal torsion
You will not qualify if you...
- Female patients aged over 18 years
- Previous surgery for adnexal pathologies
- Clinical symptoms and imaging suggesting a different surgical pathology (e.g., appendicitis, gastroenteritis)
AI-Screening
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Trial Site Locations
Total: 9 locations
1
Medical University of Graz
Graz, Austria
Actively Recruiting
2
Medical University of Vienna
Vienna, Austria
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3
IRCCS Giannina Gaslini
Genova, Italy
Actively Recruiting
4
Azienda Ospedale Università Padova
Padova, Italy
Actively Recruiting
5
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Actively Recruiting
6
Presidio Ospedaliero Santa Chiara
Trento, Italy
Actively Recruiting
7
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo"
Trieste, Italy, 34137
Actively Recruiting
8
University of Belgrade
Belgrade, Serbia
Actively Recruiting
9
University of Novi Sad
Novi Sad, Serbia
Actively Recruiting
Research Team
A
Alessandro Boscarelli, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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