Actively Recruiting
Role of Pro-Resolving Lipid Mediators in Obesity-Associated Diseases
Led by Clinica Universidad de Navarra, Universidad de Navarra · Updated on 2026-03-11
60
Participants Needed
2
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main objective of this project is to determine the possible association between the levels of certain bioactive lipids, which the body produces from dietary fatty acids, and tumor characteristics in breast cancer patients, as well as their relationship with overweight/obesity. Specific objectives are: * To analyse anthropometric and body composition changes. * To evaluate physical activity level. * To determine dietary profile. * To determine the adherence to Mediterranean dietary pattern. * To assess the quality of life. * To determine levels of specialized pro-resolving lipid mediators The target sample size is 60 subjects. Participants will be allocated in four groups: * Group 1: Postmenopausal healthy women with overweight/obesity (n=15) * Group 2: Postmenopausal healthy women with normoweight (n=15) * Group 3: Postmenopausal women with breast cancer and overweight/obesity (n=15) * Group 4: Postmenopausal women with breast cancer and normoweight (n=15)
CONDITIONS
Official Title
Role of Pro-Resolving Lipid Mediators in Obesity-Associated Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Postmenopausal for at least 1 year
- Normoweight or overweight/obesity
- For healthy participants: no personal history of cancer
- For breast cancer participants: luminal subtype breast cancer stages I-II requiring tumor removal without preoperative treatment
- Stable weight over the last 3 months (±5%) for healthy participants
- Willing to sign informed consent and follow all study procedures
You will not qualify if you...
- Personal history of cancer (for healthy participants)
- Current weight loss treatment such as diet, supplementation, or surgery
- Bariatric surgery
- No stable pharmacological treatment for at least 3 months
- Diabetes treatment and hormone replacement therapy
- Significant gastrointestinal tract abnormalities or diseases
- High alcohol intake (more than 14 units per week for women)
- Surgical interventions causing permanent gastrointestinal tract changes
- Liver disease except non-alcoholic fatty liver disease
- Cognitive or psychiatric impairments
- Poor compliance or difficulty following study procedures
- Breast cancer stages beyond II or other breast cancer types
- Requirement for preoperative treatment in breast cancer participants
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Center for Nutrition Research
Pamplona, Navarre, Spain, 31008
Actively Recruiting
2
Clínica Universidad de Navarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
Research Team
M
Miguel Burgos, PhD
CONTACT
M
María Jesús Moreno-Aliaga, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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