Actively Recruiting
The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial
Led by The Gut Microbiome Center (Centar za crijevni mikrobiom) · Updated on 2025-04-16
40
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
Sponsors
T
The Gut Microbiome Center (Centar za crijevni mikrobiom)
Lead Sponsor
C
Clinical Hospital Centre Zagreb
Collaborating Sponsor
AI-Summary
What this Trial Is About
ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to determine whether probiotic treatment can significantly modulate gut microbiome composition and functionality in endometriosis patients, specifically parameters associated with the estrobolome.
CONDITIONS
Official Title
The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult women diagnosed with stage III or IV endometriosis confirmed by biopsy
- Female gender
- Age 35 years or younger
You will not qualify if you...
- Age over 35 years
- Immunocompromised patients
- Patients with chronic inflammatory diseases such as autoimmune disorders
- Pregnancy
- Use of supplements or foods containing probiotics
- Use of immunosuppressants, antibiotics, proton pump inhibitors, or corticosteroids
- Use of probiotic products less than one month before or during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Center Zagreb
Zagreb, Croatia, 10000
Actively Recruiting
Research Team
I
Ira Renko, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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