Actively Recruiting
The Role of Proprotein-convertase-subtilisin/Kexin-type 9 in Kidney Damage in Nephrotic Syndrom
Led by Kolding Sygehus · Updated on 2025-09-09
75
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
Sponsors
K
Kolding Sygehus
Lead Sponsor
O
Odense University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Nephrotic syndrome (NS) is characterized by gross proteinuria (\>3.5 g/day), hypoalbuminaemia, edema and often hyperlipidemia. Hyperlipidemia is correlated with increased morbidity and mortality. The study aim is to investigate the role of the protein convertase subtilisin/kexin type 9 (PCSK9) in hyperlipidemia of NS, which has been suggested to play an important role. This is done by testing the following hypotheses: 1. PCSK9 is increased in patients with NS and hyperlipidemia compared to kidney-healthy controls 2. The level of PCSK9 in plasma correlates to the degree of proteinuria. 3. PCSK9 i increased in the kidney tissue of patients with NS The study will compare plasma levels of PCSK9 in correlation with degree of protein in the urine between test persons with NS and kidney healthy controls. Furthermore the investigators will study the the degree of PCSK9 in the kidney in biopsies obtained from test persons with nephrotic syndrome and test persons without proteinuria.
CONDITIONS
Official Title
The Role of Proprotein-convertase-subtilisin/Kexin-type 9 in Kidney Damage in Nephrotic Syndrom
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years old
- Patients admitted to the Medical Department and/or the Medical Emergency Department, Kolding Sygehus.
You will not qualify if you...
- Refusal to give informed consent
- Treatment with PCSK9 inhibitors
- Any acute or chronic condition that would limit the ability of the patient to participate in the study
- Control group: proteinuria
AI-Screening
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Trial Site Locations
Total: 1 location
1
Kolding Sygehus, Lillebælt Hospital
Kolding, Denmark, 6000
Actively Recruiting
Research Team
R
Rikke Z Langkilde, MD, phd
CONTACT
A
Anne D Thuesen, MD, phd
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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