Actively Recruiting
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
Led by National Taiwan University Hospital · Updated on 2025-06-04
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand the connection between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients who have been on mechanical ventilators for a long time. It focuses on patients with prolonged mechanical ventilation (PMV), a sign of chronic critical illness, where many patients struggle to successfully wean off the ventilator. The study seeks to identify important lung function factors affecting the ability to breathe independently after prolonged ventilator support. The research team will use advanced monitoring methods combining electrical impedance tomography (EIT) and esophageal pressure measurement to assess lung compliance and ventilation changes at a detailed level in tracheostomized patients receiving prolonged mechanical ventilation. These methods will measure dynamic transpulmonary driving pressure and assess regional lung overinflation and collapse during the weaning process. Participants will be observed during up to 16 weeks of synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV+PSV). Researchers will analyze lung mechanics and breathing efforts during the ventilator weaning test using these measurements. The goal is to gather clinical respiratory physiology data that could help improve strategies for successfully freeing patients from prolonged ventilator dependence.
CONDITIONS
Brief Title
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Post-tracheostomy patients transferred to the subacute respiratory care ward using respirators for at least 14 days
- At least 20 years old
- Oxygen concentration required while on the respirator does not exceed 50%
You will not qualify if you...
- Unstable vital signs or requiring continuous vasopressor use
- Pregnancy
- Chronic obstructive pulmonary disease or asthma
- Contraindications to esophageal pressure balloon placement, such as abnormal blood clotting, esophageal varices, or recent esophageal/gastric surgery within 6 months
- Contraindications to electrical impedance tomography, such as having a heart rhythm regulator device
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 16 weeks
Participants are observed while receiving synchronized intermittent mandatory ventilation with pressure support ventilation (SIMV+PSV) to assess regional lung ventilation and compliance during the weaning process.
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
J
Jih-Shuin Jerng, MD, PhD, Principal Investigator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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