Actively Recruiting
The Role and Regulatory Mechanism of Germinal Center Immune Response in Hepatitis B Virus Infection
Led by Nanfang Hospital, Southern Medical University · Updated on 2026-04-16
280
Participants Needed
1
Research Sites
319 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this observational study is to investigate the structure and composition of germinal centers in individuals with chronic HBV infection. The primary questions it aims to address are: What are the phenotypes, functions, and complexity of B cell clones of the immune cells within the germinal centers of chronic HBV-infected individuals? Do chronic HBV-infected individuals have ectopic germinal centers in the liver? This will be studied by collecting peripheral blood and discarded liver, lymph node, and tonsil tissues from chronic HBV patients undergoing lymph node surgery, hepatectomy, and tonsillectomy.
CONDITIONS
Official Title
The Role and Regulatory Mechanism of Germinal Center Immune Response in Hepatitis B Virus Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients with chronic hepatitis B or hepatitis B surface antigen-negative patients who require liver, spleen, tonsil, or lymph node surgery
- Patients who understand the study process, have signed informed consent, and agree to follow study requirements
- Patients diagnosed with chronic hepatitis B virus infection according to the 2019 prevention and treatment guidelines
You will not qualify if you...
- Patients with co-infections such as HCV, HIV, alcoholic fatty liver disease, non-alcoholic fatty liver disease, or autoimmune liver disease
- Patients with immune or coagulation system diseases, including hyperthyroidism, diabetes, or thrombocytopenic purpura
- Patients with serious underlying diseases affecting immune status
- Patients considered unsuitable for inclusion by the investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nanfang hospital, Southern Medical university
Guangzhou, Guangdong, China, 510515
Actively Recruiting
Research Team
Y
Yongyin Li
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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