Actively Recruiting
Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease
Led by Tanta University · Updated on 2025-09-10
50
Participants Needed
1
Research Sites
55 weeks
Total Duration
On this page
Sponsors
T
Tanta University
Lead Sponsor
P
Prof. Sahar Kamal Hegazy,Head of Clinical Pharmacy Department,Faculty of Pharmacy,Tanta University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Parkinson's disease (PD) is a leading neurodegenerative movement disorder, marked by a gradual loss of dopamine-producing neurons in the substantia nigra pars compacta (SNpc) and the accumulation of α-synuclein protein aggregates. Silymarin, a polyphenolic flavonoid renowned for its potent antioxidant properties, will be studied for its neuroprotective effects in PD.
CONDITIONS
Official Title
Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 45 and 65 years old
- Both sexes
- Patients with Parkinson's disease on dopamine replacement therapy
- Modified Hoehn and Yahr stage, MHY 1-4
You will not qualify if you...
- Subjects younger than 18 years of age
- Pregnant or breastfeeding women
- Suspected hypersensitivity to silymarin or multivitamins
- Advanced liver disease such as ascites, bleeding esophageal varices, or hepatic encephalopathy
- Morbid obesity with Body Mass Index (BMI) greater than 40
- Severe illness including multisystem failure, cancer, or poorly controlled diabetes with Hemoglobin A1C (HbA1C) over 7%
- Current use of Silymarin or use within the past two weeks
- Other conditions judged by investigators as unsuitable for enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tanta Hospital for Mental Health
Tanta, Tanta, Qism 2, Egypt, 31511
Actively Recruiting
Research Team
N
Nour Elsherbeny, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here