Actively Recruiting
The Role of Skin Microecology in Diabetic Skin Lesions
Led by Nanfang Hospital, Southern Medical University · Updated on 2025-06-06
200
Participants Needed
1
Research Sites
293 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is an observational study. Collect cotton swabs of the surface skin are obtained from the non-diabetic and diabetic patients hospitalized in the Nanfang Hospital of Southern Medical University. The investigators use omics technology to identify the structure and functions of cutaneous microbiome, analyze the characteristics of the skin flora of diabetic patients, and find the difference in skin microbiota among diabetic patients with different risk levels for developing into diabetic foot. Then, the participants will be followed up to compare the incidence of ulcers among different groups. And the skin tissues discarded during surgical operations of non-diabetic and diabetes patients are collected for pathological examination. Finally, based on the results of 16S high-throughput sequencing, metagenomics, etc., specific flora could be extracted from human skin flora cotton swabs, and animal experiments are performed to explore the effect of skin micro-ecology on diabetic skin lesions. The investigators will explore in animal experiments to regulate the influence of skin micro-ecology on diabetic skin lesions through treatment methods such as different hypoglycemic drugs and probiotic emulsions.
CONDITIONS
Official Title
The Role of Skin Microecology in Diabetic Skin Lesions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- For observation group: diagnosed with type 2 diabetes according to WHO 1999 criteria
- For control group: ruled out diabetes according to WHO 1999 criteria
- Participants or their family members understand and agree to participate
- Patients requiring surgical operations below the knee, such as debridement or amputation, in relevant hospital departments
- Non-diabetic patients needing surgical operations below the knee due to trauma or other reasons
You will not qualify if you...
- Presence of other skin diseases
- Use of medically prescribed soap for bathing or cosmetics on the feet
- Severe liver or kidney disease
- Immune system diseases
- HIV infection
- Malignant tumors
- Use of immunosuppressive drugs within the last four weeks
- Refusal to participate by patient or family
- Judged unsuitable by researchers to participate
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nanfang Hospital
Guangzhou, Guangdong, China, 518000
Actively Recruiting
Research Team
X
Xiaoyan Tan
CONTACT
S
Shili Zhang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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