Actively Recruiting
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Led by Ain Shams University · Updated on 2025-07-04
100
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
CONDITIONS
Official Title
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 30 and 60 years
- Both male and female participants
- Diagnosed with periodontitis stage II and/or stage III
- For ESRD group: diagnosed with end-stage renal disease and on regular hemodialysis
- ESRD group participants may have type 2 diabetes mellitus
- Participants are unrelated Egyptians from similar socioeconomic status and geographical area
- Healthy group participants have no history of systemic diseases and are not on long-term medications
You will not qualify if you...
- Current smokers
- Individuals with any systemic disease or on long-term medications (healthy group)
- Kidney transplant recipients (ESRD group)
- Individuals with systemic diseases other than diabetes (ESRD group)
- History of malignancy (ESRD group)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
hemodialysis center at Benha University Hospital.
Al Fayyum, Faiyum Governorate, Egypt
Actively Recruiting
Research Team
A
Asmaa Bakr elshaf3y, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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