Actively Recruiting
Role of Transposable Elements in Septic Immune Aging
Led by University of California, San Francisco · Updated on 2026-01-30
116
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.
CONDITIONS
Official Title
Role of Transposable Elements in Septic Immune Aging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Admitted to ICU with sepsis (Sepsis 3 Criteria)
- SOFA score of at least 2 at time of enrollment
You will not qualify if you...
- Patients on organ transplantation immunosuppression
- Patients with preexisting leukopenia
- Cancer patients receiving CAR-T therapy
- Patients under 18 years of age or otherwise deemed pediatric
- Patients with ongoing bleeding diathesis (eg, DIC, hemorrhagic shock)
- Patients with chronic hemoglobin below 7.0
- Patients who were blood transfusion dependent prior to ICU admission
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
A
Alexendar R Perez, M.D., Ph.D
CONTACT
M
Matthieu Legrand, M.D., Ph.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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