Observational Study on How Transposable Elements Affect Immune Aging and Outcomes in Adults with Sepsis in the ICU

What this Trial Is About

Researchers are investigating how levels of transposable elements may influence outcomes in patients with sepsis, focusing on whether these elements accelerate immune system aging, increase mortality, or raise the risk of secondary infections in intensive care unit ICU patients. This observational study involves adults diagnosed with sepsis who meet Sepsis 3 Criteria, alongside healthy individuals for comparison. The research is led by the University of California, San Francisco. Participants include adults aged 18 and older admitted to the ICU with sepsis and a SOFA score of at least 2, as well as healthy controls not hospitalized. The study involves collecting blood samples from all participants for RNA and DNA sequencing to analyze genetic factors related to immune aging and infection outcomes. No additional treatments or interventions are provided during the study. During the study, researchers will evaluate immune system aging over six weeks and monitor mortality and secondary infections within 30 days. Blood draws and genetic sequencing form the primary assessments, with ongoing observation of patient health status in the ICU. Participation does not involve extra procedures beyond standard blood collection, and the study is expected to continue until August 2028.

Role of Transposable Elements in Septic Immune Aging