Actively Recruiting
The Role of Ultrasonography in Pregnancy in the Study of Fetal Central Nervous System Malformations
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-30
80
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This research aims to explore the relationship between new ultrasound imaging patterns and malformations of the fetal central nervous system (CNS). It focuses on understanding brain development during pregnancy by analyzing ultrasound scans, seeking to identify clearer patterns that may improve the diagnosis of fetal brain abnormalities. The study compares ultrasound images from fetuses diagnosed with CNS malformations to those from healthy fetuses, helping to better characterize these malformations. The study involves reviewing ultrasound images routinely taken during pregnancy for two groups: fetuses with CNS malformations and healthy fetuses without such abnormalities. Data collected includes maternal age, pregnancy history, conception method, family history, type and timing of CNS malformation diagnosis, pregnancy outcomes, and newborn health measures such as sex, weight, and neurological assessment shortly after birth. Participants will provide information about their pregnancies and allow access to ultrasound images previously obtained. Researchers will assess correlations between ultrasound patterns and fetal CNS malformations as the main outcome. Additional comparisons between affected and healthy fetuses are planned. The study spans up to 100 weeks, including prenatal imaging review and postnatal newborn assessments, with ongoing monitoring of pregnancy outcomes and neurological health.
CONDITIONS
Brief Title
The Role of Ultrasonography in Pregnancy in the Study of Fetal Central Nervous System Malformations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women older than 18 years with a single pregnancy and fetus diagnosed by ultrasound with central nervous system malformation (group A)
- Women with a single pregnancy and a fetus without anatomical CNS abnormalities (group B)
You will not qualify if you...
- Twin pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Retrospective analysis covering images from January 2000 to May 2021
Participants' ultrasound images routinely performed during pregnancy are reviewed to study fetal central nervous system malformations and identify new ultrasound patterns.
Ultrasound images are reviewed from routine prenatal scans
Duration - Up to 100 weeks
Participants' pregnancy outcomes and newborn health data are collected and monitored following the ultrasound evaluations.
Follow-up data collected from medical records after birth
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Bologna, Italy, 40138
Actively Recruiting
Research Team
G
Gianluigi Pilu, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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