Actively Recruiting
The Role of Vitamin K on Knee Osteoarthritis Outcomes
Led by Boston University · Updated on 2026-01-23
55
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
Sponsors
B
Boston University
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most commonly used forms and doses include phylloquinone (vitamin K1; 1000µg or 500µg daily) or menaquinone-7 (MK-7 or vitamin K2; 300µg daily). However, whether these doses are adequate to increase vitamin K to levels that ameliorate risk of adverse OA outcomes is not known. Furthermore, although some studies suggest enhanced bioavailability of MK-7 over vitamin K1, as well as extra-hepatic effects, whether this is relevant for an older population with knee OA is not known, The overall goal of this pilot randomized clinical trial (RCT) is to test different subtypes and doses of vitamin K supplementation in older adults with knee OA and to measure changes in relevant biochemical measures.
CONDITIONS
Official Title
The Role of Vitamin K on Knee Osteoarthritis Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 60 years old or older
- Clinical diagnosis of knee osteoarthritis by the treating rheumatologist
- Ability to speak and understand English
You will not qualify if you...
- Current use of anticoagulant medications such as warfarin, dabigatran, rivaroxaban, or apixaban
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Boston Medical Center, Rheumatology Clinic
Boston, Massachusetts, United States, 02118
Actively Recruiting
Research Team
J
Jean Liew, MD MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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