Actively Recruiting
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome
Led by Ain Shams University · Updated on 2025-10-03
60
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Long-term glucocorticoids therapy is associated with various complications, including decreased bone strength (Glucocorticoid-induced osteoporosis) and an increased risk of fracture. Vitamin K2 has been recently deemed appreciable as a topic of research as it plays a pivotal role in maintenance of the bone strength, and it has been proved to have a positive impact on the bone metabolism. This study examines the impact of oral vitamin K2 supplementation on bone metabolism in pediatric patients with nephrotic syndrome on long-term steroid therapy, offering valuable therapeutic insights
CONDITIONS
Official Title
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Nephrotic patients under 16 years of age of both genders who were treated with glucocorticoids for the first time
- Glucocorticoid treatment started at 2 mg/kg/day prednisolone with gradual dose reduction
- Patients have been on glucocorticoid therapy for more than 6 months
- Patients have sufficient vitamin D levels of 30 ng/ml (75 nmol/L) or above
You will not qualify if you...
- Patients with impaired kidney functions
- Non-compliant patients on medications or vitamin supplements
- Diseases affecting fat-soluble vitamin absorption such as gallbladder or biliary disease, cystic fibrosis, celiac disease
- History of vitamin K-related disorders like bleeding disorders or osteomalacia
- History of bone fracture before the study
- Any nephrotic syndrome with identified genetic causes
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ain Shams University
Cairo, Egypt
Actively Recruiting
Research Team
N
Noha Saied Ibrahim, Teaching Assistant
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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