Actively Recruiting
ROSE-Longitudinal Assessment With Neuroimaging
Led by State University of New York at Buffalo · Updated on 2025-07-04
250
Participants Needed
7
Research Sites
295 weeks
Total Duration
On this page
Sponsors
S
State University of New York at Buffalo
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neuroimaging cohort of ROSE to obtain long-term neuroimaging and identical assessments longitudinally to address critical questions regarding the progressive decline of patients 12 to 24 months post intracerebral hemorrhage (ICH) with long term cognitive follow-up to 36 months on average. This proposal would represent the largest, and longest advanced neuroimaging and RNA-sequencing evaluation after ICH to date.
CONDITIONS
Official Title
ROSE-Longitudinal Assessment With Neuroimaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or greater, fulfillment of the criteria for Deep, Subcortical or Lobar Intracerebral Hemorrhage
- No evidence of trauma, vascular malformation or aneurysm, or brain tumor as a cause of ICH
- Ability of the patient or legal representative to provide informed consent
You will not qualify if you...
- Brainstem or Cerebellar ICH
- Patients severely affected by the ICH, early mortality, hospice, or withdrawal of care not eligible for ROSE
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
University of Illinois Chicago
Chicago, Illinois, United States, 60612
Actively Recruiting
2
Baptist Health Louisville
Louisville, Kentucky, United States, 40207
Actively Recruiting
3
University of Maryland
Baltimore, Maryland, United States, 21201
Actively Recruiting
4
Columbia University
New York, New York, United States, 10032
Actively Recruiting
5
Duke University
Durham, North Carolina, United States, 27710
Actively Recruiting
6
University of Cincinnati
Cincinnati, Ohio, United States, 45267
Actively Recruiting
7
Houston Methodist
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
L
Lee A Gilkerson, RN, BSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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