Actively Recruiting
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Led by Bettina Mittendorfer · Updated on 2026-05-07
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a study to check the accuracy and consistency of various laboratory tests, equipment, and devices used for research on chronic diseases, nutrition, and metabolism. This includes participants who are healthy or have endocrine, cardiometabolic, and musculoskeletal disorders. The goal is to ensure that new testing methods produce reliable results compared to older methods as technology advances. Participants may undergo tests such as blood and urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance tests, and consuming test meals. Imaging techniques like MRI, DEXA, and MRS, along with adipose and muscle biopsies, and non-invasive endothelial function tests may also be performed. These procedures help researchers evaluate different assays and sample treatments and repeat tests to confirm accuracy and reproducibility. During the study, participants will have various assessments and laboratory tests to measure outcomes including insulin, urinalysis, glucose tolerance, vascular function, tissue biopsies, and multiple blood and urine markers. These tests will be repeated and compared over up to six months to validate their consistency. The study involves healthy volunteers and individuals with specific health conditions, with all tests conducted under research supervision to monitor results closely.
CONDITIONS
Brief Title
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 100 years
- Body mass index between 16.0 and 60 kg/m2
You will not qualify if you...
- Younger than 18 or older than 100 years
- Body mass index less than 16.0 or greater than 60 kg/m2
- Allergies, intolerances, or dietary restrictions to meal ingredients; vegans or vegetarians
- Use of medications or dietary supplements that could interfere with the tests being evaluated
- Engaged in regular structured exercise more than 150 minutes per week unless needed for test validation
- Significant organ dysfunction or diseases except those needed for test validation
- Alcohol use disorder or use of controlled substances unless required for test validation
- Pregnant women, persons who smoke, prisoners, or inability to give voluntary informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 months
Participants undergo various assessments including blood and urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance tests, test meal consumption, imaging such as MRI, DEXA, MRS, and tissue biopsies to evaluate and validate laboratory assays and research techniques.
1 to multiple visits depending on the tests performed and repeat assessments
Trial Site Locations
Total: 1 location
1
University of Missouri-Columbia
Columbia, Missouri, United States, 65211
Actively Recruiting
Research Team
S
Study coordinator
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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