Actively Recruiting

Age: 18Years - 75Years
All Genders
Healthy Volunteers
NCT06286761

Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

Led by Bettina Mittendorfer · Updated on 2025-07-20

100

Participants Needed

1

Research Sites

199 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases (obesity, pre-diabetes and type-2 diabetes, dyslipidemia, non-alcoholic fatty liver disease, cardiovascular disease, etc.), nutrition, and metabolism (the process by which a substance is handled in your body) at the University of Missouri. As technology changes and we start to use new testing methods, it is necessary to compare results from old tests, equipment and devices and new tests, equipment, or devices and the reproducibility of these measurements to make sure we are getting accurate results. Reproducibility means performing the same test more than once to see if the same results can be achieved each time.

CONDITIONS

Official Title

Routine Validation and Reproducibility Testing of Laboratory Measures and Research Techniques Used for Metabolism Research (VAL)

Who Can Participate

Age: 18Years - 75Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • 18 and 75 years of age
  • Body mass index between 18.5 and 45 kg/m2
  • Weight stable with less than 3% change
  • At least 150 minutes of structured exercise per week for at least 2 months before the study
  • Blood glucose below 126 mg/dl when fasting and below 200 mg/dl after 2-hour oral glucose tolerance test
  • Hemoglobin A1C (HbA1C) 6.5% or less
  • Dyslipidemia with triglycerides 125 mg/dL or less
  • No chronic kidney disease
  • Not vegan, vegetarian, or on high protein diets or disallowed supplements
  • No allergies or intolerances to study diet ingredients
  • No excessive alcohol or tobacco use
Not Eligible

You will not qualify if you...

  • Younger than 18 or older than 75 years
  • Body mass index below 18.5 or above 45 kg/m2
  • History or current significant organ system dysfunction such as heart disease, stroke, diabetes, cancer in remission less than 5 years, dementia, or chronic kidney disease
  • Allergies or intolerances to meal ingredients
  • Vegan or vegetarian diet
  • Use of medications that may affect study outcomes like anti-inflammatories or immune modulators
  • Use of dietary supplements such as certain pre- and pro-biotics, fiber, or fish oil
  • Engaged in structured exercise more than 150 minutes per week
  • Alcohol use disorder or use of controlled substances
  • Pregnant women
  • Tobacco users
  • Prisoners
  • Inability to give voluntary informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

University of Missouri School of Medicine

Columbia, Missouri, United States, 65212

Actively Recruiting

Loading map...

Research Team

H

Heather McHatton, MPH, RN

CONTACT

V

Vasavi Shabrish, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here