Actively Recruiting
Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment and the Potential Role of Therapeutic Drug Monitoring in UK Infection Management
Led by Imperial College London · Updated on 2024-05-23
323
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the use of beta-lactam antibiotics among patients treated for infections at Imperial College Healthcare NHS Trust. The study aims to find out how many patients achieve the desired drug levels to optimize treatment success, reduce drug toxicity, and help limit antibiotic resistance. It also seeks to identify groups where drug dosage adjustments may be needed and develop new research ideas to improve antibiotic use. Participants who are being treated for infection and have received or will soon receive beta-lactam antibiotics will be observed during their care at the NHS Trust. Their clinical information will be collected from electronic health records and biological samples will be taken to measure drug concentrations. The study will last for three years, during which various antibiotics and patient outcomes will be monitored and analyzed. During the study, participants will provide informed consent and allow access to their medical records and samples for drug level analysis. Researchers will track clinical factors, co-administered medications, infection biomarkers, and treatment responses to understand how well drug targets are met. The main outcome is the proportion of patients achieving target drug concentrations. This observational study will help inform future dose optimization research and support better infection management.
CONDITIONS
Brief Title
Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or above
- Under follow-up for management of infection at Imperial College NHS Trust
- Received a beta-lactam antibiotic within the last 48 hours or are planned to start imminently
- Provides informed written consent or has a personal consultee declaration due to delirium, suspected/confirmed central nervous system infection, or critical illness requiring sedation/intubation related to infection
You will not qualify if you...
- Less than 18 years of age
- Severe anaemia (Hb < 70g/l)
- Platelets < 50x10^9/l, INR >1.5, or other known blood clotting impairment
- Terminal diagnosis receiving palliative care who may experience distress if approached
- Enrolled in a clinical trial excluding participation in other studies
- Patients with restricted liberty, prisoners, or under legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 years
Participants who undergo routine care for infection management at Imperial College NHS Trust are observed. Clinical data are collected from electronic healthcare records and samples are taken for drug concentration analysis to evaluate antimicrobial target attainment.
Visits occur as part of routine healthcare; additional sample collections may occur during treatment
Trial Site Locations
Total: 1 location
1
Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0HS
Actively Recruiting
Research Team
S
Suzy Williams
R
Richard Wilson, MPharm
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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