Actively Recruiting

Phase Not Applicable
Age: 40Years - 80Years
FEMALE
ID05848141

Indoor Rowing as a Novel Exercise Therapy for Cardiovascular Rehabilitation in Middle-Aged and Older Breast Cancer Survivors Following Chemotherapy

Led by University of Florida · Updated on 2025-08-17

72

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the impact of a new exercise program using indoor rowing on cardiovascular rehabilitation in middle-aged and older breast cancer survivors who have completed chemotherapy. This study focuses on those who have a higher risk of heart disease due to their prior cancer treatment and aims to find ways to reduce this risk through targeted exercise. The research is sponsored by the University of Florida and involves women aged 40 to 80 years who have been treated for non-metastatic breast cancer stages I-III. Participants in the study will be randomly assigned to either a supervised indoor rowing exercise group or receive usual care with no intervention. Those in the rowing group will be trained on how to use the rowing machine and gradually build up to 50 minutes of moderate-intensity exercise, three times per week, over 12 weeks. After completing their assessments, participants in the usual care group may also have the opportunity to try the rowing program. Throughout the study, researchers will monitor heart function using specific measures such as brachial flow-mediated dilation and global longitudinal strain before and after the 12 weeks of training. They will track how well participants adhere to the exercise plan by recording frequency, duration, and intensity of workouts. Safety will be carefully observed by noting any adverse events during the exercise program. Overall, participation lasts for about 12 weeks, with evaluations conducted at the start and end of the exercise period.

CONDITIONS

Brief Title

Rowing Following Breast Cancer Chemotherapy

Who Can Participate

Age: 40Years - 80Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of primary invasive non-metastatic breast cancer, stages I-III
  • Female based on biological sex
  • Aged between 40 and 80 years
  • Completed breast cancer treatment 6 to 24 months prior to enrollment
  • Allowed to be on adjuvant endocrine therapy, CDK4/6 inhibitors, PARP inhibitors, HER2 targeted agents, immunotherapy, and bisphosphonates within 6 months prior and during study
  • No contraindications to exercise or study participation
  • Approval from study clinician
Not Eligible

You will not qualify if you...

  • Receiving or scheduled to receive breast cancer treatment (chemotherapy, surgery, or radiation) during study participation
  • Lymphedema stage 2 or higher before enrollment
  • Relevant cardiovascular diseases such as stroke, heart failure, myocardial ischemia, myocardial infarction, angina, or coronary procedures
  • Participation in other experimental interventions that may affect study results
  • Regular participation in 150 minutes or more per week of moderate-intensity rowing exercise in the past 6 months

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Outpatient Treatment

Duration - 12 weeks

Participants receive supervised indoor rowing exercise training progressing to 50 minutes of moderate-intensity exercise, 3 days per week.

Weekly visits for up to 12 weeks

Trial Site Locations

Total: 1 location

1

Integrative Cardiovasculal Physiology Laboratory, University of Florida

Gainesville, Florida, United States, 32611

Actively Recruiting

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Research Team

D

Demetra Christou, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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