Actively Recruiting
rTMS for Apathy Clinical Trial
Led by Sunnybrook Health Sciences Centre · Updated on 2026-04-13
10
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in neurocognitive disorders and mild behavioural impairment in individuals receiving methylphenidate and individuals not receiving medication for apathy.
CONDITIONS
Official Title
rTMS for Apathy Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mild or major neurocognitive disorder OR mild behavioural impairment
- Apathy for at least 4 weeks
- Stable dose of medication (>4 weeks) that may affect cognition or behaviour
- Care partner who spends at least 10 hours a week with the subject
You will not qualify if you...
- Current major depressive episode
- Agitation, delusions, or hallucination
- Medical contraindications to rTMS
- Currently taking an amphetamine product
- Central nervous system abnormalities, Tourette's syndrome, or motor tics
- Current participation in another clinical trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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