Actively Recruiting
Led by Shanghai Mental Health Center · Updated on 2025-02-11
26
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating a treatment for individuals aged 13 to 35 with Clinical High-risk Syndrome of Psychosis (CHR). The study aims to explore personalized brain stimulation targets identified using magnetoencephalography (MEG) to better understand and treat abnormal brain signals related to this condition. Participants have either not started antipsychotic medication or maintain stable medication and dosage during the study. The approach is individualized based on each person's brain activity. The study is divided into two parts. First, MEG scans locate abnormal brain signals during rest and task states to determine 2 to 4 specific targets for intervention. Second, participants receive repetitive transcranial magnetic stimulation (rTMS) at these personalized targets. The rTMS involves low-frequency 1Hz stimulation, with 1400 pulses per session at 100% exercise threshold, each lasting 23 minutes. The treatment starts with 10 days of pseudo stimulation over 2 weeks, followed by a 2-week rest, then 10 days of real stimulation over weeks 3 and 4. Rest periods of 30 to 60 minutes occur between targeting sessions. Participants undergo scale evaluations before and after pseudo and real stimulation phases, with follow-up visits at 7, 14, 30, 60, and 90 days after treatment ends. Researchers measure the reduction rates on clinical assessment scales such as SIPS/SOPS and PNASS to evaluate changes. The study includes detailed monitoring of symptoms and brain responses to develop individualized treatment plans for CHR in clinical practice.
CONDITIONS
RTMS for CHR Based on Personalized Targets Using Magnetoencephalography
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 weeks
Participants undergo magnetoencephalography (MEG) to collect resting and task state data and identify precise brain targets for intervention based on abnormal brain signals.
1 to 2 visits depending on data collection
Duration - 6 weeks total including rest
Participants receive a pseudo stimulation intervention using low-frequency rTMS for 10 days over 2 weeks, followed by a 2-week rest period, then 10 days of real rTMS stimulation over 2 weeks targeting 2-4 brain areas per session.
5 visits per week during intervention weeks for a total of 20 visits
Duration - 3 months
Participants have follow-up evaluations to assess treatment effects on days 7, 14, 30, 60, and 90 after the intervention ends.
5 follow-up visits
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, China, 200030
Actively Recruiting
Y
Yegang Hu, Doctor
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Yingying Tang, Lihua Xu, Tianyuan Zhu...
https://pubmed.ncbi.nlm.nih.gov/36841956TianHong Zhang, LiHua Xu, YanYan Wei...
https://pubmed.ncbi.nlm.nih.gov/38741342