Actively Recruiting
rTMS to Improve Cognition in Parkinson's
Led by VA Office of Research and Development · Updated on 2026-04-21
56
Participants Needed
2
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.
CONDITIONS
Official Title
rTMS to Improve Cognition in Parkinson's
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans seeking services at Hines VA Hospital or Jesse Brown VA Medical Center
- Diagnosis of Parkinson's disease or atypical parkinsonism confirmed by a neurologist
- Meet criteria for mild cognitive impairment
- On stable medication with no changes expected during the study
- Able to speak and read English
- 50 years of age or older
You will not qualify if you...
- Diagnosis of dementia
- Inability to demonstrate decision-making capacity
- History of deep brain stimulation surgery
- Severe depression
- Presence of resting head tremor
- Dyskinesia interfering with imaging data collection
- Congestive heart failure
- Implanted cardiac pacemaker or defibrillator
- Cochlear implant, nerve stimulator, or intracranial metal clips
- Implanted medical pump
- Increased intracranial pressure
- History of claustrophobia
- Metal in eyes or face, shrapnel or bullet remnants in brain
- History or family history of seizure or epilepsy
- History of stroke, head injury, or unexplained seizures
- Other neurological diseases affecting seizure threshold, including CVA, cerebral aneurysm, dementia, increased intracranial pressure
- Use of medications that lower seizure threshold such as tricyclic antidepressants or neuroleptics
- Secondary conditions affecting electrolyte balance or seizure threshold
- Inability to determine motor threshold for rTMS dosing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Jesse Brown VA Medical Center, Chicago, IL
Chicago, Illinois, United States, 60612
Not Yet Recruiting
2
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, United States, 60141-3030
Actively Recruiting
Research Team
S
Sandra L Kletzel, PhD BA
CONTACT
A
Alexandria N Umbarger, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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