Actively Recruiting
rTMS as an Intervention for Levodopa-induced Dyskinesia
Led by Danish Research Centre for Magnetic Resonance · Updated on 2024-08-28
68
Participants Needed
1
Research Sites
144 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD). Specifically, the study aims to determine whether patterned stimulation of the pre-supplementary motor area (pre-SMA) can delay the onset of LID after levodopa intake and reduce LID severity in PD patients. This study will provide critical insights into potential targets for rTMS treatment, optimal rTMS parameters, and the mechanisms underlying LID in Parkinson's disease.
CONDITIONS
Official Title
rTMS as an Intervention for Levodopa-induced Dyskinesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically established or probable Parkinson's Disease
- Meets Clinical Diagnostic Criteria for Parkinson's Disease
- Has peak-of-dose levodopa-induced dyskinesia
- On stable antiparkinsonian medication for at least four weeks
- Able and willing to provide signed informed consent
You will not qualify if you...
- Presence of psychiatric disorders
- Using antipsychotic medication, Donepezil, or GABAergic drugs like pregabalin or gabapentin
- Regular use of benzodiazepines or opioids more than once per week
- History of neurological diseases other than Parkinson's Disease
- History of epilepsy or increased risk of seizures from TMS
- Close relatives with epilepsy or related seizure risk conditions
- Contraindications for MRI scans
- Pregnant or not using contraception if female of childbearing age
- Refusal to be informed about new health information or accidental findings during the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
DRCMR
Hvidovre, Denmark, 2650
Actively Recruiting
Research Team
L
Laura Sakalauskaite, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
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