Actively Recruiting
rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease
Led by West Virginia University · Updated on 2026-04-20
20
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.
CONDITIONS
Official Title
rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinician-confirmed diagnosis of Parkinson's Disease
- Ability to provide informed consent, written and verbal
- Clinician-diagnosed impulse control disorder or impulse control behaviors including punding/hobbyism and dopamine dysregulation syndrome
- Beck Depression Inventory (BDI) score of 14 or lower
- Montreal Cognitive Assessment (MoCA) score of 20 or higher
- On dopamine-replacement therapy
You will not qualify if you...
- History of seizures or epilepsy
- History of brain lesions such as multiple sclerosis or tumor
- History of vascular brain issues such as stroke
- History of moderate to severe traumatic brain injury
- Major psychiatric illness such as schizophrenia or depression (BDI score of 14 or higher)
- Significant cognitive impairment (MoCA score below 20)
- Had transcranial magnetic stimulation (TMS) within the past year
- Pregnancy (for female patients)
- Presence of intracranial metallic objects (except dental fillings)
- Current use of substances or medications that significantly lower seizure threshold
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
West Virginia University Hospitals
Morgantown, West Virginia, United States, 26505
Actively Recruiting
Research Team
M
Mariya V Cherkasova, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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