Actively Recruiting
rTMS Response Trajectories in Depression
Led by Chinese University of Hong Kong · Updated on 2024-02-12
70
Participants Needed
1
Research Sites
591 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression has remained substantial despite the health care cost and time incurred. There remains a compelling clinical need to find valid biomarkers to inform personalized treatment. Using supervised machine learning on 4 combined features of neuroimaging markers, our group recently reported excellent prediction for clinical response in 70 patients receiving TMS to left dorsolateral prefrontal cortex for medication-resistant major depression in 2015-18 (Phase 1 study).The clinical utility of these potential neuroimaging biomarkers is still uncertain without further validation of the trained model in an independent clinical cohort.
CONDITIONS
Official Title
rTMS Response Trajectories in Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Right-handed
- Diagnosis of major depressive disorder according to DSM-IV
- Moderate or more severe episode with MADRS score >20 and HDRS 17-item score >18
- Failed to respond to at least one full course (>6 weeks) of antidepressant medication or medication intolerant
You will not qualify if you...
- Significant head trauma
- Active abuse of alcohol or illegal substances
- Current psychotic symptoms
- Suicide ideation or recent suicide attempts
- Other DSM-IV Axis I and II psychiatric diagnoses
- Neurological disorders
- Contraindications to fMRI (e.g., pacemakers, metal implants, pregnancy) or rTMS
- Electroconvulsive therapy within the past year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry, CUHK
Hong Kong, Hong Kong, 852
Actively Recruiting
Research Team
T
The Department of Psychiatry
CONTACT
H
Helene J Hopman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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