Non-Invasive Brain Stimulation Using rTMS to Reduce Spasticity in Children Aged 7 to 18 With Hemiplegic Cerebral Palsy

What this Trial Is About

Researchers are evaluating the effects of repetitive transcranial magnetic stimulation rTMS on children aged 7 to 18 years with hemiplegic cerebral palsy, focusing on reducing upper limb spasticity. This trial compares active rTMS with a sham procedure to see if rTMS followed by intensive limb training can improve muscle control and function. The study also explores brain changes using MRI and TMS techniques to understand how these treatments might work. Participants are randomly assigned to one of two groups. The intervention group receives 1 Hz active rTMS for 20 minutes, followed by 30 minutes of intensive training of the impaired limb. The control group receives a sham rTMS treatment for the same 20 minutes, also followed by 30 minutes of intensive limb training. Both groups undergo treatment sessions over 10 days. During the study, children will have MRI scans before and after treatment to investigate brain changes. Researchers will assess spasticity using the Modified Ashworth Scale and range of motion scores at day 10, day 17, and two months after intervention. Additional measures include functional scales, quality of life assessments, and motor function tests. The study lasts for several months, with follow-up visits to monitor long-term effects.

rTMS Treatment of Spasticity in Children With Cerebral Palsy/ Hemiplegia Due to ABI - a RCT