What is this study evaluating for Mild Cognitive Impairment?

This study is evaluating whether combining brain stimulation with virtual reality cognitive training improves thinking skills, mood, daily functioning, and quality of life in people with Mild Cognitive Impairment. It also looks at how these treatments might reduce caregiver burden. The research is led by the Central Arkansas Veterans Healthcare System to explore new non-drug treatment options.

Who may be eligible for this Mild Cognitive Impairment clinical trial?

Adults aged 55 or older with a previous diagnosis of Mild Cognitive Impairment may be eligible. Both men and women can participate. Important factors include passing safety screening for brain stimulation, not having seizure risks or certain neurological conditions, and not having implanted devices. Please review eligibility criteria for more details.

Is there any cost to participate in this Mild Cognitive Impairment clinical trial?

Study-related care, including the brain stimulation, virtual reality training, and all trial visits, is provided at no cost. Personal travel expenses or other costs may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Phase Not Applicable

Age: 55Years +

All Genders

Healthy Volunteers

ID06024473

A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for Mild Cognitive Impairment

Led by Central Arkansas Veterans Healthcare System · Updated on 2025-02-20

Participants Needed

Research Sites

22 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating whether a combination of brain stimulation and cognitive training can improve thinking skills and mood in older adults diagnosed with Mild Cognitive Impairment MCI. This study focuses on using repetitive Transcranial Magnetic Stimulation rTMS along with an immersive virtual reality cognitive training program iVCT to see if these therapies together help more than brain stimulation alone or no intervention. The research also looks at effects on mental health, daily functioning, quality of life, and caregiver burden. Participants will be assigned to one of three groups a control group receiving usual care with no intervention, a group receiving rTMS treatments five days a week for two weeks total 10 sessions, or a group receiving rTMS followed by 30 to 60 minutes of virtual reality cognitive training each day for the same two-week period. All participants will undergo initial assessments before treatment. During the study, participants will complete evaluations at the start, two weeks after treatment, and three months later to measure changes in cognitive abilities, emotional health, daily functioning, and caregiver burden. Tests include the Hopkins Verbal Learning Test and other questionnaires. The study aims to understand both immediate and lasting effects of these therapies over several months, with total participation lasting about three months.

CONDITIONS

Brief Title

A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI

Who Can Participate

Age: 55Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Age 55 and over
Previous diagnosis of Mild Cognitive Impairment
Score of 18 or over on the MoCA during pre-screening procedures

You will not qualify if you...

Under 55 years old
Do not pass the TMS Adult Safety Screening
Taking medications known to increase risk of seizure
Taking ototoxic medications
Having an implanted medical device
History of bipolar disorder
History of Tourette's syndrome or presence of motor tics
History of seizures or seizures in first-degree relatives
History of stroke, aneurysm, or cranial neurosurgery
Current alcohol-related disorder needing medical treatment
History of abnormal electroencephalogram (EEG)
History of motion sickness, nausea, vomiting, seizures, or migraine
Significant balance or gait impairments or history of falls
History of hyperacusis or photophobia

Research Team

Ian Moore, PhD

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