Actively Recruiting
A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for Mild Cognitive Impairment
Led by Central Arkansas Veterans Healthcare System · Updated on 2025-02-20
50
Participants Needed
1
Research Sites
22 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether a combination of brain stimulation and cognitive training can improve thinking skills and mood in older adults diagnosed with Mild Cognitive Impairment (MCI). This study focuses on using repetitive Transcranial Magnetic Stimulation (rTMS) along with an immersive virtual reality cognitive training program (iVCT) to see if these therapies together help more than brain stimulation alone or no intervention. The research also looks at effects on mental health, daily functioning, quality of life, and caregiver burden. Participants will be assigned to one of three groups: a control group receiving usual care with no intervention, a group receiving rTMS treatments five days a week for two weeks (total 10 sessions), or a group receiving rTMS followed by 30 to 60 minutes of virtual reality cognitive training each day for the same two-week period. All participants will undergo initial assessments before treatment. During the study, participants will complete evaluations at the start, two weeks after treatment, and three months later to measure changes in cognitive abilities, emotional health, daily functioning, and caregiver burden. Tests include the Hopkins Verbal Learning Test and other questionnaires. The study aims to understand both immediate and lasting effects of these therapies over several months, with total participation lasting about three months.
CONDITIONS
Brief Title
A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55 and over
- Previous diagnosis of Mild Cognitive Impairment
- Score of 18 or over on the MoCA during pre-screening procedures
You will not qualify if you...
- Under 55 years old
- Do not pass the TMS Adult Safety Screening
- Taking medications known to increase risk of seizure
- Taking ototoxic medications
- Having an implanted medical device
- History of bipolar disorder
- History of Tourette's syndrome or presence of motor tics
- History of seizures or seizures in first-degree relatives
- History of stroke, aneurysm, or cranial neurosurgery
- Current alcohol-related disorder needing medical treatment
- History of abnormal electroencephalogram (EEG)
- History of motion sickness, nausea, vomiting, seizures, or migraine
- Significant balance or gait impairments or history of falls
- History of hyperacusis or photophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 weeks
Participants receive assigned interventions, either rTMS daily for 5 days a week for 2 weeks, rTMS followed by virtual reality cognitive training daily for 5 days a week for 2 weeks, or usual care without intervention.
Daily visits 5 days per week for 2 weeks
Duration - 3 months after treatment
Participants complete post-treatment assessments to evaluate cognitive, emotional, and functional abilities and caregiver burden.
2 visits (at 2 weeks and 3 months post-treatment)
Trial Site Locations
Total: 1 location
1
Central Arkansas VA Healthcare system
Little Rock, Arkansas, United States, 72114
Actively Recruiting
Research Team
I
Ian Moore, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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