Actively Recruiting
rTMS With and Without Text4Support for the Treatment of Resistant Depression.
Led by University of Alberta · Updated on 2026-04-13
200
Participants Needed
2
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter prospective, parallel design, two-arm, rater-blinded randomized controlled pilot trial. Participants will be randomly assigned to one of two treatment conditions. In the first condition, treatment consists of rTMS sessions combined with Text4Support. The second condition is made up of the treatment as usual (rTMS sessions alone). The recruitment process is scheduled to last 12 months. It will involve active treatment for six weeks and follow-up period observation periods of 1,3, and 6 months for participants in both arms of the study. Participants will be recruited from four different centers for this project. Two centers (the Addiction and Mental Health clinic and the Alberta day hospital) will be from the large, sociodemographic diverse city of Edmonton in Alberta Western Canada. The remaining two centers will be in Halifax and Annapolis Valley in Nova Scotia, Canada.
CONDITIONS
Official Title
rTMS With and Without Text4Support for the Treatment of Resistant Depression.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years and older
- Diagnosed with major depressive disorder according to DSM-5 criteria
- Have failed two or more standard antidepressant treatments during the current episode
- May be on psychotropic medications including antidepressants, antipsychotics, benzodiazepines, and anticonvulsants
- Good understanding of the English language
- Have access to a smartphone and able to receive and read text messages
- Willing to provide written informed consent
You will not qualify if you...
- Under 18 years of age
- Have neurological disorders such as history of seizures, central nervous system tumors, cerebrovascular disease, stroke, cerebral aneurysm, or movement disorders
- Have current psychotic disorders including substance-induced psychosis, psychotic disorder due to a medical condition, or MDD with psychotic features
- Have current personality disorders that affect cognition or ability to participate
- Have learning disabilities identified through medical history or assessment
- Participated in any drug or device clinical trial within the last six weeks or plan to participate during this study
- Are pregnant or breastfeeding
- Any condition identified by investigators that may interfere with study participation or outcome assessments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Edmonton Mental Health Clinic
Edmonton, Alberta, Canada, T6R 3P5
Actively Recruiting
2
Nova Scotia Health - Abbie J. Lane Memorial Building QEII Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H 2E2
Actively Recruiting
Research Team
V
Vincent Agyapong, MD, Ph.D
CONTACT
M
Medard K Adu, BEd, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here