Actively Recruiting
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease
Led by Italian Sarcoma Group · Updated on 2026-01-02
100
Participants Needed
28
Research Sites
511 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma
CONDITIONS
Official Title
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed diagnosis (brachyury expression) of primary sacral chordoma of any size and location from S1 to coccyx
- Age 18 years or older
- ECOG performance status 0 to 2
- No previous antineoplastic therapy
- Macroscopic tumor visible on MRI or CT scan
- Patient suitable for surgery
- Patient suitable for radiotherapy
- Written informed consent given before enrollment according to ICH/GCP guidelines
You will not qualify if you...
- Presence of distant metastasis
- Inability to maintain treatment position
- Previous radiotherapy to the pelvic region
- Prior treatment for sacral chordoma including surgery, cryoablation, or hyperthermia
- Local conditions increasing risk of radiotherapy toxicity (such as ulcerated skin infiltration, infection, fistula in treatment area)
- Rectal wall infiltration by tumor
- General conditions increasing radiotherapy toxicity risk (active sclerodermia, xeroderma pigmentosum, cutaneous porphyria)
- Having a second active cancer except certain in-situ neoplasias
- Severe comorbidities with prognosis under 6 months
- Inability to give informed consent
- Other malignancy within the last 5 years
- ECOG performance status 2 or higher
- Significant cardiovascular disease (e.g., dyspnea greater than NYHA 2)
- Significant systemic diseases grade higher than 3 on NCI-CTCAE scale or judged to increase treatment toxicity
- Women who are pregnant or breastfeeding
- Psychological, social, family, or geographic circumstances limiting protocol compliance or consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 28 locations
1
Medical University of Graz
Graz, Austria
Actively Recruiting
2
EBG GmbH MedAustron
Wiener Neustadt, Österreich, Austria, 2700
Actively Recruiting
3
Medical Faculty Carl Gustav Carus Faculty of Medicine, Department of Radiation Oncology,
Dresden, Germany
Not Yet Recruiting
4
University Hospital Carl Gustav Carus Dresden
Dresden, Germany
Not Yet Recruiting
5
University Hospital Essen. West German Proton Therapy Center Essen
Essen, Germany
Actively Recruiting
6
Heidelberg Ion-Beam Therapy Center - HIT
Heidelberg, Germany
Not Yet Recruiting
7
National Center for Spinal Disorders
Budapest, Hungary
Not Yet Recruiting
8
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, MI, Italy, 20133
Actively Recruiting
9
Istituto Ortopedico Rizzoli
Bologna, Italy, 40136
Actively Recruiting
10
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy, 50134
Not Yet Recruiting
11
Istituto Clinico Humanitas
Milan, Italy, 20089
Actively Recruiting
12
I.R.C.C.S. Istituto Ortopedico Galeazzi
Milan, Italy, 20161
Active, Not Recruiting
13
Centro Nazionale di Adroterapia Oncologica - CNAO
Pavia, Italy, 27100
Actively Recruiting
14
II Clinica Universitaria Ortopedia e Traumatologia AO Pisa
Pisa, Italy, 56124
Actively Recruiting
15
Istituto Regina Elena - IFO
Rome, Italy, 00100
Actively Recruiting
16
Agenzia Provinciale per la Protonterapia - AtreP
Trento, Italy, 38122
Active, Not Recruiting
17
Saitama Medical Center
Saitama, Japan
Actively Recruiting
18
Netherlands Cancer Institute
Amsterdam, Netherlands
Not Yet Recruiting
19
Leiden University Medical Center
Leiden, Netherlands
Not Yet Recruiting
20
Norwegian Radium Hospital/Oslo Univeristi Hospital
Oslo, Norway, N-0424
Actively Recruiting
21
Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie
Warsaw, Poland
Active, Not Recruiting
22
H. Val D'Hebron
Barcelona, Spain
Actively Recruiting
23
Hosptial San Pau
Barcelona, Spain
Active, Not Recruiting
24
H. San Carlos
Madrid, Spain
Not Yet Recruiting
25
Hospital Universitario Virgen del Rocío
Seville, Spain
Actively Recruiting
26
Hospital Universitario Doctor Peset
Valencia, Spain, 46017
Not Yet Recruiting
27
The Royal Orthopaedic Hospital
Birmingham, United Kingdom
Not Yet Recruiting
28
Royal National Orthopaedic Hospital
London, United Kingdom
Not Yet Recruiting
Research Team
A
Alessandro Gronchi, MD
CONTACT
I
ISG Clinical Trial Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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