Actively Recruiting
Use of D-dimers in the Emergency Department to Identify Adult Patients at Very Low Risk of Mortality for Fast-track Treatment - a Randomized Controlled Study
Led by Odense University Hospital · Updated on 2025-04-09
1538
Participants Needed
2
Research Sites
4 weeks
Total Duration
On this page
Sponsors
O
Odense University Hospital
Lead Sponsor
S
Slagelse Sygehus
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the use of D-dimer testing in emergency departments to identify adult patients at very low risk of mortality. This study focuses on patients who arrive with non-specific complaints and aims to see if providing D-dimer test results to physicians can speed up the decision process for discharge. The trial is a randomized controlled study led by Odense University Hospital and addresses the challenge of increasing patient numbers in emergency settings. Participants will be randomly assigned to either usual care or care guided by D-dimer test results. The D-dimer test is performed on arrival, and in the intervention group, physicians are informed of the results to help guide treatment decisions. The study specifically targets patients who are stable, ambulatory, and have normal vital signs, with follow-up periods lasting up to 30 days. During the study, participants' length of stay from arrival to physician decision within 4 hours is measured as the primary outcome. Secondary outcomes include 7- and 30-day all-cause mortality, total hospital length of stay within one month, and any re-contacts to the emergency department within 30 days. Participants will undergo standard blood tests and vital sign assessments, and their progress will be monitored through hospital records and follow-up visits until discharge or 30 days after arrival.
CONDITIONS
Brief Title
The Safe Fast Track Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or above
- Able to provide oral and written informed consent in Danish
- Blood tests ordered on arrival as part of standard of care
- Ambulatory on arrival or walking to the ambulance (i.e., stable independent gait)
- Normal vital signs (i.e., National Early Warning Score < 3)
You will not qualify if you...
- Unstable condition requiring immediate care in the resuscitation area
- Triage level red (i.e., the most urgent patients)
- Trauma (minor and major) patients
- High likelihood of requiring a D-dimer analysis on clinical indications during the current hospital contact that will be ordered on arrival regardless of this study
- Previous participation in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 4 hours from arrival to physician decision
Participants receive usual care or care guided by D-dimer test results during their emergency department visit.
1 visit (in-person)
Duration - 30 days from arrival
Participants are monitored for outcomes including mortality, hospital length of stay, and emergency department re-contacts.
Follow-up contacts as needed within 30 days
Trial Site Locations
Total: 2 locations
1
Esbjerg Hospital
Esbjerg, Syd, Denmark, 6700
Actively Recruiting
2
Odense University Hospital
Odense, Syd, Denmark, 5000
Not Yet Recruiting
Research Team
M
Mette Løkke, RN
M
Mikkel Brabrand, MD PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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