Actively Recruiting
Safety of Anal Curcumin
Led by Lisa Flowers · Updated on 2025-04-23
48
Participants Needed
2
Research Sites
41 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to see if curcumin can reverse anal high-grade squamous intraepithelial lesions (aHSIL) (high-grade anal precancerous cells or high-grade abnormal cells) in people living with HIV to avoid current treatments such as ablation (destroying abnormal cells with heat or surgical excision (cutting out the abnormal cells)), which have potential short- and long-term side effects.
CONDITIONS
Official Title
Safety of Anal Curcumin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 30 years of age or older
- Have biopsy-proven anal intraepithelial neoplasia (AIN) 2 or AIN 3 without previous treatment
- Or have cytology results showing ASC-H or HSIL
- Able and willing to complete a study diary
- Other inclusion criteria apply
You will not qualify if you...
- Have a clinically significant progressive chronic medical condition such as coronary disease, congestive heart failure, chronic obstructive lung disease, or diabetes mellitus
- History of anal cancer
- Pregnant or planning pregnancy within the next three months
- History of sensitivity or allergy to any compound used in this study
- Have Grade 2 or higher renal or hematology abnormalities
- Current or past year use of intravenous drugs (except therapeutic use), recreational drugs, or alcohol abuse
- Other exclusion criteria apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Grady Memorial Hospital
Atlanta, Georgia, United States, 30303
Actively Recruiting
2
Grady Hospital - Ponce De Leon Clinic
Atlanta, Georgia, United States, 30308
Actively Recruiting
Research Team
L
Lisa Flowers, MD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
8
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