Actively Recruiting

All Genders
NCT07172620

Safety and Effectiveness of No-touch Technique for Ascending Aorta in MICS-CABG

Led by Peking University Third Hospital · Updated on 2025-09-15

260

Participants Needed

1

Research Sites

291 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this single-center prospective cohort study is to compare perioperative safety metrics and follow-up survival analyses in patients receiving Minimally Invasive Cardiac Surgery Coronary Artery Bypass Grafting(MICS-CABG) and Off-Pump Coronary Artery Bypass(OPCAB). The main question it aims to answer is: Is the bridge vessel patency rate of patients in the MICS-Notouch group noninferior to that of a saphenous vein bridge with conventional open-chest bypass? Participants will be divided into two groups: Exposure group (MICS-Notouch group): non-extracorporeal circulation multiple coronary artery bypass grafting surgery performed under direct visualization of a small incision in the left chest, including the application of LIMA (left internal mammary artery) + SVG (saphenous vein) multiple bypass grafting. Control group (OPCAB group): conventional median chest opening, non-extracorporeal circulation multi-branch coronary artery bypass graft surgery.

CONDITIONS

Official Title

Safety and Effectiveness of No-touch Technique for Ascending Aorta in MICS-CABG

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with angina limiting daily life or work despite medical treatment who need coronary artery bypass grafting confirmed by coronary angiography
  • Patients with calcification of the ascending aorta confirmed by CT who cannot have sidewall clamping
Not Eligible

You will not qualify if you...

  • Old, large myocardial infarction with no surviving myocardium, significant heart enlargement, EF less than 30%, left ventricular diameter over 70mm, ventricular wall tumor, or severe arrhythmia causing hemodynamic instability
  • Valve or other intracardiac surgery planned at the same time
  • Expected need for extracorporeal circulation surgery
  • Poor myocardial infarction condition, extensive lesions, distal or diffuse stenosis, or severe calcification preventing anastomosis
  • Previous open heart surgery
  • Preoperative hemodynamic instability requiring emergency surgery
  • Terminal malignant tumors, uncontrollable infections, bleeding, severe brain injury, multiple organ failure, or serious organ function impairment
  • Inability to tolerate surgery
  • Declined participation in the study

AI-Screening

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Trial Site Locations

Total: 1 location

1

Peking University Third Hospital

Beijing, Beijing Municipality, China, 100191

Actively Recruiting

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Research Team

G

Gong Yichen, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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