Actively Recruiting
Safety and Efficacy of Combination of Tamsulosin 0.4 mg Plus Tadalafil 5mg Versus 2.5 mg
Led by Ain Shams University · Updated on 2026-05-01
140
Participants Needed
1
Research Sites
31 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ureteral stenting is a common urological procedure performed to relieve obstruction and facilitate urinary drainage. Despite its effectiveness, stent-related symptoms (SRS) such as dysuria, frequency, urgency, flank pain, and sexual discomfort negatively affect patient quality of life. Pharmacological management with alpha-blockers such as Tamsulosin and phosphodiesterase-5 inhibitors (PDE5i) such as Tadalafil has shown promise in reducing SRS. While low-dose Tadalafil (2.5 mg) has not been explored, its comparative effectiveness against the standard 5 mg dose when combined with Tamsulosin remains under-researched. This study aims to evaluate the difference in reduction of SRS between Tamsulosin with Tadalafil in standard and half dosage.
CONDITIONS
Official Title
Safety and Efficacy of Combination of Tamsulosin 0.4 mg Plus Tadalafil 5mg Versus 2.5 mg
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years of age
- Presence of a double-J (DJ) stent (polyurethane) after endoscopic stone removal
You will not qualify if you...
- Patients younger than 18 years of age
- History of prostate or bladder surgery
- Prior lower urinary tract procedures
- History of cancer
- Presence of neurological conditions
- History of pelvic radiation
- Diagnosis of diabetes
- Kidney dysfunction (acute or chronic)
- Presence of a solitary kidney
- Congenital urinary anomalies
- Current use of alpha-blockers, beta-blockers, calcium channel blockers, 5-alpha reductase inhibitors, PDE5 inhibitors, anticholinergics, or nitrates
- Cardiac issues
- Residual stone fragments after surgery
- Multiple or bilateral ureteral stones
- Long-term or bilateral stents requiring frequent changes
- Interstitial cystitis
- Chronic cystitis
- Prostatitis
- Pregnancy
- Breastfeeding
- Unavailability for follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ain Shams University Hospital
Cairo, Abbasia, Egypt
Actively Recruiting
Research Team
A
Ahmed Amr Mohammed Mounier, MSc
CONTACT
W
Waleed Mousa, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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