Comparing Safety and Effectiveness of Tamsulosin 0.4 mg with Two Doses of Tadalafil 2.5 mg vs 5 mg for Symptoms from Ureteric Stents

What this Trial Is About

Ureteral stenting is a common urological procedure used to relieve blockage and aid urinary drainage, but it often causes bothersome symptoms such as pain, frequent urination, urgency, and sexual discomfort, which can reduce quality of life. Researchers are studying the effects of combining two drugs, Tamsulosin and Tadalafil, at different doses to see how well they reduce these stent-related symptoms in patients who have had stones removed endoscopically and have a ureteral stent in place. The trial compares two groups of about 70 patients each. One group will take Tamsulosin 0.4 mg with a low dose of Tadalafil 2.5 mg daily, while the other group takes Tamsulosin 0.4 mg with a standard Tadalafil dose 5 mg daily. The study aims to find out if the lower dose of Tadalafil combined with Tamsulosin is as effective in easing symptoms caused by the ureteral stent as the higher dose combination. Participants will be monitored over 4 weeks to evaluate stent-related symptoms. The study includes regular assessments of urinary symptoms and pain related to the stent. The research team will carefully review the safety and effectiveness of both treatment combinations during this period. The total participation time aligns with the 4-week symptom evaluation, and researchers will monitor patients for any side effects or changes in symptoms throughout the study.

Safety and Efficacy of Combination of Tamsulosin 0.4 mg Plus Tadalafil 5mg Versus 2.5 mg