Actively Recruiting
Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis
Led by NMD Pharma A/S · Updated on 2026-04-13
84
Participants Needed
40
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This Phase 2 proof-of-concept, dose range finding study aims to evaluate the safety and efficacy of 3 dose levels of NMD670 vs placebo in adult patients with MG with antibodies against AChR or MuSK, administered twice a day (BID) for 21 days.
CONDITIONS
Official Title
Safety and Efficacy of 3 Dose Levels of NMD670 in Adult Patients With Myasthenia Gravis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be a male or female being 18 or more, at the time of signing the informed consent
- Diagnosis of MG, MGFA class II, III or IV
- Documented positive AChR or MuSK antibody test.
- Participant must be able to swallow tablets
- Body mass index between 18 and 35 kg/m2, inclusive, at screening, and with a minimum weight of 40 kg
- Contraceptive use by men and women must be consistent with local regulations regarding the methods of contraception for those participating in clinical studies
- Participant is capable of and has given signed informed consent
You will not qualify if you...
- Known medical or psychological condition(s) or risk factor that, in the opinion of the Investigator, might interfere with the patient's full participation in the study, pose any additional risk for the patient, or confound the assessment of the patient or outcome of the study
- Participants with other significant clinical and/or laboratory safety findings that may interfere with the conduction or interpretation of the study
- Participants that received treatment with an investigational medical product within 30 days or 5 half-lives of the medication, whichever is longer prior to Day 1
- Participants with history of poor compliance with relevant MG therapy
- Female patients who plan to become pregnant during the study or are currently pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
Profound Research LLC
Carlsbad, California, United States, 92011
Withdrawn
2
University of California Irvine Medical Center
Irvine, California, United States, 92868
Actively Recruiting
3
University of Colorado Neuromuscular Division
Aurora, Colorado, United States, 80045
Actively Recruiting
4
SFM Clinical Research, LLC
Boca Raton, Florida, United States, 33487
Actively Recruiting
5
Neuromuscular Research Division | University of South Florida
Tampa, Florida, United States, 33612
Actively Recruiting
6
Augusta University, Neuroscience Center
Augusta, Georgia, United States, 30912
Actively Recruiting
7
NextGen Precision Health
Columbia, Missouri, United States, 65212
Actively Recruiting
8
The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
9
The Ohio State University
Columbus, Ohio, United States, 43221
Actively Recruiting
10
University of Oregon
Portland, Oregon, United States, 97239
Actively Recruiting
11
Semmes Murphey Clinic
Memphis, Tennessee, United States, 38120
Actively Recruiting
12
UZ Leuven
Leuven, Belgium
Withdrawn
13
Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
14
Rigshospitalet University of Copenhagen
Copenhagen, Denmark
Actively Recruiting
15
Centre de référence des maladies neuromusculaires AOC-CHU de Bordeaux - Hôpital Pellegrin
Bordeaux, France
Actively Recruiting
16
Centre de Référence des Maladies Neuromusculaires et de la SLA
Marseille, France
Actively Recruiting
17
Centre Hospitalier Universitaire de Nantes - Hôtel Dieu Centre de Référence des Maladies Neuromusculaires Rares -
Nantes, France
Actively Recruiting
18
CHU de Nice
Nice, France
Actively Recruiting
19
Unité de Recherche Clinique NeuroSciences
Nice, France
Actively Recruiting
20
JSC Curatio
Tbilisi, Georgia
Actively Recruiting
21
LTD David Tatishvili Health Center
Tbilisi, Georgia
Actively Recruiting
22
Ltd New Hospitals
Tbilisi, Georgia
Actively Recruiting
23
ASST Papa Giovanni XXIII (Azienda Ospedaliera Papa Giovanni XXIII)
Bergamo, Italy, 21127
Actively Recruiting
24
IRCCS Istituo delle Scienze neurologiche di Bologna, UOC Clinica neurologica Ospedale
Bologna, Italy, 40139
Actively Recruiting
25
IRCCS Ospedale Policlinico San Martino
Genova, Italy, 16132
Actively Recruiting
26
IRCCS Fondazione Istituto Neurologico Carlo Besta, Dipartimento di Ricerca e Sviluppo clinico
Milan, Italy, 20133
Actively Recruiting
27
DIMER, IRCCS, Ospedale San Raffaele
Milan, Italy
Actively Recruiting
28
Centro Sclerosi Multipla Napoli - AOU Vanvitelli
Naples, Italy, 80138
Actively Recruiting
29
AOU Pisana
Pisa, Italy, 56126
Actively Recruiting
30
Azienda Ospedaliera Sant'Andrea - Universita di Roma La Sapienza
Roma, Italy, 00189
Actively Recruiting
31
Leiden Universitair Medisch Centrum (LUMC)
Leiden, Netherlands, 2333
Actively Recruiting
32
Neurologia Śląska Centrum Medyczne
Katowice, Poland
Actively Recruiting
33
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie sp.z o.o
Krakow, Poland
Actively Recruiting
34
Centrum Medyczne Hope Clinic
Lublin, Poland, 20701
Actively Recruiting
35
Galen Clinic
Lublin, Poland
Actively Recruiting
36
NeuroCor Banaszkiewicz, Tomaszewski Lekarze Spółka Partnerska
Myślenice, Poland
Actively Recruiting
37
Centrum Medyczne Neuro Protect
Warsaw, Poland
Actively Recruiting
38
University Clinical Center of Serbia, Neurology Clinic
Belgrade, Serbia
Actively Recruiting
39
University Clinical Center Nis, Neurology Clinic
Niš, Serbia
Actively Recruiting
40
Hospìtal Universitari Vall d'Hebrón
Barcelona, Spain
Actively Recruiting
Research Team
N
NMD Pharma A/S
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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