Actively Recruiting
Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis
Led by CHA University · Updated on 2025-05-31
102
Participants Needed
2
Research Sites
267 weeks
Total Duration
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AI-Summary
What this Trial Is About
The purpose of this study is to investigate the safety and efficacy of early administration of two different doses of dexamethasone in high risk septic patients.
CONDITIONS
Official Title
Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sepsis defined by Sepsis-3 definition
- Initial systolic blood pressure less than 90 mmHg or blood lactate level over 2 mmol/L
- Age 19 years or older
You will not qualify if you...
- Advanced directive for "Do not resuscitation"
- Systemic glucocorticoid use within 4 weeks
- Systemic chemotherapy within 4 weeks
- Systemic immunosuppressant use within 4 weeks
- Expected life expectancy less than 90 days
- Transferred from another hospital
- Sepsis diagnosis made more than 24 hours after emergency department admission
- Use of etomidate in emergency department
- Pregnant or breastfeeding
- No informed consent given
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Bundang CHA hospital
Seongnam-si, Gyeonggi-do, South Korea, 13488
Actively Recruiting
2
Samsung Hospital
Seoul, South Korea, 06351
Actively Recruiting
Research Team
K
Kyuseok Kim, M.D, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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