Actively Recruiting
Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2024-05-07
100
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to awaken, time to extubation, time to mechanical ventilation, time in the ICU, and on delirium.
CONDITIONS
Official Title
Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mechanically ventilated with oral endotracheal intubation in the ICU
- Aged over 18 years and under 70 years
- Expected mechanical ventilation time greater than 24 hours
You will not qualify if you...
- Known or suspected allergy to esketamine, dexmedetomidine, remifentanil, or propofol
- Pregnancy or lactation
- Obesity with Body Mass Index over 35 kg/m2
- Extreme hemodynamic or respiratory instability due to severe burn or trauma (Injury Severity Score 65)
- Heavy drinking as defined by WHO (at least 60g pure alcohol daily for men, 40g for women)
- Terminally ill patients near death, such as with metastatic tumors or refractory shock
- Long-term use of sedatives, opioid analgesics, or antianxiety drugs
- Severe central nervous system diseases such as stroke, status epilepsy, or coma
- Acute or chronic severe liver disease (Child-Pugh class C or liver transplant history)
- Acute or chronic kidney failure requiring dialysis
- Refusal to provide informed consent
- Mechanically ventilated for more than 24 hours before enrollment (excluding time in operation room)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China, 225500
Actively Recruiting
Research Team
Z
Zuo Xiangrong
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here