Actively Recruiting

Phase 1
Phase 2
Age: 18Years +
MALE
NCT03424850

Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy

Led by Washington University School of Medicine · Updated on 2026-03-11

36

Participants Needed

1

Research Sites

626 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this research study is to learn more about the outcomes and early and late side effects of treating early stage prostate cancer with high dose rate brachytherapy.

CONDITIONS

Official Title

Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy

Who Can Participate

Age: 18Years +
MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Histologically or cytologically confirmed early stage prostate cancer
  • Low-risk (T1-T2a, Gleason 64 6, PSA < 10 ng/mL) or favorable intermediate-risk (Gleason 3+4=7, < 50% positive biopsy cores, no more than one NCCN intermediate risk factor)
  • Prior androgen deprivation therapy allowed if started within 6 months before HDR implant, lasting 4 to 36 months
  • At least 18 years old
  • ECOG performance status 64 2
  • Able to understand and willing to sign informed consent or have a legally authorized representative do so
Not Eligible

You will not qualify if you...

  • Prior radiation therapy to prostate or lower pelvis including prostate
  • History of other cancers within past 5 years except treated basal or squamous cell skin carcinoma
  • Currently receiving other investigational agents
  • Uncontrolled illnesses such as active infection, symptomatic heart failure, unstable angina, or arrhythmia
  • Unable to undergo general, spinal, or local anesthesia
  • Prior transurethral resection of the prostate (TURP) causing a large defect compromising implant integrity

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Washington University School of Medicine

St Louis, Missouri, United States, 63110

Actively Recruiting

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Research Team

H

Hiram A Gay, M.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

TREATMENT

Number of Arms

3

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