Comparing Intensity-Modulated Proton and Radiation Therapy for Breast Cancer Safety and Effectiveness Study with 5-Year Follow-Up

What this Trial Is About

Researchers are studying breast cancer patients who need radiotherapy to compare two types of radiation treatments intensity-modulated proton therapy IMPT and intensity-modulated radiation therapy IMRT. The goal is to evaluate and compare the side effects and effectiveness of these two therapies when used before, after, or as the main treatment for breast cancer. The study will follow patients for at least five years to observe treatment safety, cancer recurrence, survival, and quality of life. Eligible patients will receive radiotherapy targeting the whole breast, chest wall, and regional lymph nodes. Treatment plans may include a boost dose for high-risk areas, decided by the radiation oncologist. Three treatment groups include patients receiving postoperative, preoperative, or definitive radiotherapy using either IMPT or IMRT. Different radiation schedules are allowed, including hypofractionated, conventional fractionated, or ultra-hypofractionated regimens, tailored to patient needs. Participants will be monitored regularly for acute side effects within six months and for late side effects, cancer recurrence, survival, and other outcomes over five years. Assessments include tracking radiation-induced toxicities, cancer control measures, and quality of life. The study also checks tumor response after preoperative or definitive radiotherapy. This long-term follow-up aims to provide comprehensive information on the safety and impact of these radiation therapies in breast cancer care.

Safety and Efficacy of IMPT or IMRT for Breast Cancer