Actively Recruiting
Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum
Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2025-12-04
30
Participants Needed
3
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present study will investigate the safety of inferior mesenteric artery embolization prior to rectal surgery, according to IDEAL recommendations (Lancet 2009). It aims to assess the safety of endovascular embolization of the inferior mesenteric artery prior to surgery in patients with rectal tumors, and estimate the potential benefits in terms of time to surgery and the occurrence of post-operative fistulas.The study will also assess the impact of subacute ischemia induced by IMA embolization on colonic vasculature remodeling, colonic ischemic suffering, altered hemostasis and initiation of neo-angiogenesis through blood sampling kinetics.The hypothesis is that ischemic preconditioning by inferior mesenteric artery embolization prior to rectal cancer resection surgery is safe and will result in a decrease in acute relative colon ischemia and a reduction in the rate of fistulas and post-surgical complications. Indeed, we believe that the beneficial effects of the ischemic preconditioning of IMA will be due to better blood perfusion of the colon at 3 weeks, which is apparently linked to remodeling and/or the development of collateral vascularization.
CONDITIONS
Official Title
Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with rectal cancer eligible for surgery with ligation at the origin of the inferior mesenteric artery.
- Patients with free, informed consent.
- Patients affiliated to or benefiting from a health insurance plan.
You will not qualify if you...
- Patients with a history of colon cancer who has undergone colon resection surgery.
- Patients with occlusion of the superior mesenteric artery or stenosis of more than 50%, visible on CT scan.
- Patients with occlusion of the inferior mesenteric artery on the extension scan.
- Patients with systemic bleeding disorders or on anticoagulant therapy.
- Patients taking corticosteroids or immunosuppressants posing high surgical risk.
- Patients with renal insufficiency (clearance < 30 mL/min).
- Patients allergic to iodine.
- Patients treated for abdominal aorta or its branches.
- Patients participating in another interventional study or in exclusion period.
- Patients under court protection, guardianship, or curatorship.
- Patients unable to give or receive informed consent.
- Pregnant or breastfeeding patients.
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Trial Site Locations
Total: 3 locations
1
Hôpital Saint-Eloi
Montpellier, France, 34295
Actively Recruiting
2
Institut du Cancer de Montpellier
Montpellier, France, 34298
Actively Recruiting
3
CHU de Nîmes
Nîmes, France, 30029
Actively Recruiting
Research Team
M
Martin BERTRAND, Professor
CONTACT
A
Anissa MEGZARI
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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