Actively Recruiting
Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
Led by Yi Yang · Updated on 2024-10-02
100
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine the efficacy and safety of levofloxacin combined with intravenous thrombolysis in treating acute ischemic stroke
CONDITIONS
Official Title
Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-75 years
- Acute ischemic stroke patients treated with intravenous thrombolysis using alteplase (0.9 mg/kg)
- Modified Rankin Scale score 1 or less before stroke onset
- National Institute of Health stroke scale (NIHSS) score between 5 and 15, with level of consciousness less than 1
You will not qualify if you...
- Undergoing endovascular treatment
- Use of glucocorticoids, class I or III antiarrhythmic drugs, or quinolones within 14 days
- Presence of diseases that increase risk of adverse drug reactions, including ventricular arrhythmias, prolonged QT interval, severe cardiac insufficiency (NYHA grade 3 or higher), myasthenia gravis, peripheral neuropathy, seizures, tendon diseases, severe immune or hematological diseases, active hepatitis or cirrhosis, or serious respiratory diseases
- Abnormal liver or kidney function exceeding specified limits
- Current infection
- Fasting blood glucose below 3.9 mmol/L
- Symptomatic intracranial hemorrhage confirmed before randomization
- Allergy to fluoroquinolones or other antibiotics
- Life expectancy less than 3 months or inability to complete the study
- Unwillingness to be followed up or poor treatment compliance
- Participation in other clinical studies within 3 months before enrollment or participation in this study
- Other conditions unsuitable for enrollment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
First Hospital of Jilin University
Changchun, Jilin, China, 130000
Actively Recruiting
Research Team
Y
Yi Yang, MD, PhD
CONTACT
Z
Zhen-Ni Guo, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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